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Figure  5: Effects of gto on spiral-wave meandering patterns. (a) Tip-trajectory evolution for different gto values during 220 ms. (a.I) gto = 0.0050 mS is the value for the standard guinea-pig ventricle model, (a.II) gto = 0.0 mS - Ito is blocked, (a.III) gto= 0.0025 mS - half the standard value, (a.IV) gto = 0.01mS - double the standard value. Action potential configurations with different gto values are shown superimposed for single (b) and repetitive stimulation (c). The inset plots in (b) and (c) are magnifications of the corresponding parts of the main plot. The gto values are given in the legend (tin s, Vin mV).